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KMID : 0363420130270040057
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Journal of Korean Oriental Pediatrics
2013 Volume.27 No. 4 p.57 ~ p.67
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Comparisons of Effects of Biman-tang according to Administration Period in Childhood Obesity
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Lim Young-Kwern
Min Seo-Rim
Kim Hee-Man
Hur Kwang-Wook
Lee Hoon
Lee Jin-Soo
Kim Ho-Cheol
Park Jae-Woo
Park Hi-Joon
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Abstract
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Objectives: The purpose of this study is to investigate the safety and effect of Biman-tang (BMT) on two different administration periods in the treatment of childhood overweight and obesity.
Methods: In retrospective study, 39 overweight and obese (85th percentile ≤ Body Mass Index (BMI)) children were treated with BMT from January 2006 to April 2013 at Korean Medical Clinic in Suwon, Korea. The primary outcomes were the changes in BMI and Obesity Index (OI) from baseline to the treatment groups. Secondary outcomes included the changes in height, weight and safety of the medicine. Comparisons of BMI, OI, height and weight between the short-period (SP) treatment group and the long-period (LP) treatment group were done by using ANCOVA.
Results: The change of the mean of BMI (-0.5 ± 0.6 kg/m2 vs -1.4 ± 0.8 kg/m2, respectively; p=0.003) and OI (-3.6± 3.9% vs -9.7 ± 4.7%, respectively; p<0.001) showed significant reduction both in SP (n=16) and LP treatment group (n=23). The mean height showed no significant difference in both groups. The mean weight of LP treatment group showed significant reduction compared to SP treatment group (-0.2 ± 1.3 kg vs -1.6 ± 1.6 kg, respectively; p=0.006). Most of the children were compliant to the medication and no serious adverse events were found in two groups.
Conclusions: These findings emphasize that BMT is effective in the treatment of childhood obesity and it requires at least
45 days of treatment for the best result.
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KEYWORD
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Children and adolescence, Obesity, Overweight, Korean traditional medicine, Herbal medicine
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